Fgf21
-
Official Full Name
fibroblast growth factor 21 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008] -
Synonyms
FGF21;fibroblast growth factor 21
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rat
- Zebrafish
- Bovine
- Pig
- E.coli
- E. coli
- HEK293
- N-mFc-Avi
- Insect Cell
- Human Cell
- Mammalian Cell
- Bovine
- CHO
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- HEK293F
- Mammalian cells
- Non
- His
- N-His
- N-mFc-Avi
- His&S
- Flag
- Fc
- HIS
- Myc&DDK
- GST
- mFc&Avi
- His&Fc&Avi
- His&GST
Involved Pathway
Fgf21 involved in several pathways and played different roles in them. We selected most pathways Fgf21 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgf21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | EPAS1,BIRC8,FZD7,PLCB1,BDKRB2,PIK3CG,LAMC2,MLH1,GNB2,TRAF2 |
| Melanoma | IGF1,PIK3CG,CDH1,FGF19,FGF9,PIK3R2,MITF,AKT2,PTEN,FGF14 |
| Rap signaling pathway | GNAI2,VEGFC,FGFR4,ITGB2,NRAS,PARD6B,VEGFB,FGF4,MAPK11,PRKD2 |
| Ras signaling pathway | PLCE1,NGF,TEK,PLCG1,RAC2,PDGFRA,CALM3,IGF1,IGF1R,RASA3 |
| Regulation of Actin Cytoskeleton | ITGAE,BRAF,SCINLB,PFN4,INS,ACTB1,SRC,ITGA6B,FGF10,ITGA2 |
| MAPK signaling pathway | FGF22,RELA,RAF1B,FGFR1,FGFR1A,ARRB2A,RPS6KA2,PPM1A,HSPA1B,FGF7 |
| PIK-Akt signaling pathway | PPP2R5E,FGF3,PGF,BCL2L1,CASP9,OSMR,TSC1,FGF11,G6PC3,YWHAB |
Protein Function
Fgf21 has several biochemical functions, for example, fibroblast growth factor receptor binding,growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgf21 itself. We selected most functions Fgf21 had, and list some proteins which have the same functions with Fgf21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CD300LH,TH,FANCI,DCSTAMP,DACT2,C1orf38,FXN,CLN6,CNOT1,LRP1 |
| fibroblast growth factor receptor binding | Fgf15,FGF1A,FGF22,FGF8B,FGF10,FRS3,FGF8,FGF10B,FGF1,FRS2 |
| growth factor activity | CECR1,FGF8A,FGF6A,FGF6,PGF,FGF22,GDNFA,CSF1,BMP8A,LIF |
Interacting Protein
Fgf21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgf21 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgf21.
KLB;CDC25A;MAPK7;TNS2;CDH7
Fgf21 Related Signal Pathway
Resources
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References
- Umberger, TS; Sloan, JH; et al. Novel sandwich immunoassays for the measurement of total and active FGF21. BIOANALYSIS 6:3283-3293(2014).
- Zhang, J; Li, Y; et al. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. DRUG DISCOVERY TODAY 19:579-589(2014).