CDH2
-
Official Full Name
cadherin 2, type 1, N-cadherin (neuronal) -
Overview
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008] -
Synonyms
CDH2;cadherin 2, type 1, N-cadherin (neuronal);CDHN;NCAD;CD325;CDw325;cadherin-2;N-cadherin 1;neural cadherin;neural-cadherin;cadherin 2, N-cadherin (neuronal);calcium-dependent adhesion protein, neuronal
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Rhesus macaque
- Zebrafish
- Bovine
- Mus musculus
- Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
- Rhinolophus ferrumequinum (Greater horseshoe bat)
- Callithrix jacchus (White-tufted-ear marmoset)
- Human Cells
- HEK293
- E.coli
- Mammalian Cells
- Wheat Germ
- Insect Cells
- Rabbit
- Fc
- His
- GST
- Flag
- Strep II
- Non
- hIgG4
- Avi
- DDK
- Myc
Involved Pathway
CDH2 involved in several pathways and played different roles in them. We selected most pathways CDH2 participated on our site, such as Adherens junctions interactions,Arrhythmogenic right ventricular cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | ITGB1B.1,CDH11,PVRL1A,CDH12,CDH6,CLDN16,CADM2A,CDH10,CDH5,LIMS1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CTNNA3,ITGA4,CACNA2D2,ITGA2,CACNB2,ITGB8,CACNB3,SGCA,Itga10&Itgb1,CTNNA1 |
| Adherens junctions interactions | CDH24,ANG,CDH12A,CDH6,JUPA,CDH10,CDH13,CDH3,CDH4,CTNND1 |
| Cell-Cell communication | CADM2,CADM2B,F11R.2,DST,CDH12,PLEC,CADM2A,CDH18A,CDH12A,CDH8 |
| BDNF signaling pathway | CSNK2A1,EIF4EBP1,EGR1,EIF2S1,SIRPA,MAP3K2,DPYSL2,JAK2,CFL1,EEF2 |
| Cell adhesion molecules (CAMs) | HLA-DPA1,CLDN4,PVRL3B,ITGB2,CD58,HLA-F,NLGN4A,MHC1UEA,ITGA6,CD34 |
| Arrhythmogenic right ventricular cardiomyopathy | DSP,CACNG2,DES,JUP,CTNNA1,DSG2,CACNG3,DMD,DAG1,DSC2 |
| CDO in myogenesis | MYOD1,MEF2B,CTNNA1,TCF3B,BNIP2,BOC,CDH4,SPAG9,MYOG,CTNNA2 |
Protein Function
CDH2 has several biochemical functions, for example, alpha-catenin binding,beta-catenin binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH2 itself. We selected most functions CDH2 had, and list some proteins which have the same functions with CDH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase binding | PPP1R3C,SKAP1,VCAN,EIF2AK3,PARD3,STAT3,CSK,KAT2A,MET,MAPK14 |
| beta-catenin binding | LEF1,PARK2,ASH2L,PSEN1,SALL1,MED12,AXIN2,CDH1,CTNNBIP1,CHD8 |
| calcium ion binding | THBS4A,GUCA1B,TBC1D9,CASQ1A,CALRL2,CANT1,SYT5B,MASP2,ANXA2,S100A12 |
| protein binding | TTC8,PRCP,ARMC8,MYBBP1A,TMEM182,FIGNL1,DOK1,RBMX,JAG1,RHOG |
| protein kinase binding | VDAC1,TRAF3,FAM83E,TPX2,CAMK2N1,MSN,FGF19,SLC12A7,STAT3,PRKCZ |
| protein complex binding | ST13,CDK2,ABP1,KAT6B,MLKL,CRHR1,BCAP31,PPIB,ATG101,PFKP |
| alpha-catenin binding | NUMB,JUPA,JUP,CDH24,AJUBA,VCL,CTNNB1,PKP2,PKP3,JUB |
| nitric-oxide synthase binding | SLC14A2,NOS1AP,CAV1,DMD,CD74,SNTA1,CALM2,DNM2,SCN5A,ACTB |
| gamma-catenin binding | PTPRJ,TCF7L2,Fert2,LEF1,DSG1A,PTPRK,CDH1,APC,DSG1,FER |
Interacting Protein
CDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH2.
CTNNB1;PTPRC;PTPRB;PTPRG;PTPN6;PTPN7;PTPN12;PTPRJ;PTPRR;PTPRK;PTPRO;PTPN22;CTNND1;PRKAR1A;JUP;EXOC5
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