Human Cancer Antigen CA15-3 (Breast Cancer) Calibrator Grade

• Cat.No.: CDA003

Specification

• Cat. No.: CDA003
• Description: CA15-3 is a tumor marker used to monitor certain cancers, especially breast cancer. Elevated CA15-3, in conjunction with alkaline phosphatase, was shown to improve chances of early recurrence in breast cancer.
• Source: Human fluid
• Format: Calibrator grade, Liquid
• Purification: High Speed Centrifugatiom,Salt precipitation,delipidization
• Concentration: Specific Protein: 11, 5 KUnits/ml (Roche ELICA)
• Buffer: PBS, pH 7.4 ± 0.2
• preservative: 0.1% Sodium azide
• Applications: Specific methodologies have not been tested using this product.
• Storage: Short-term store at 2-8℃. Long term store at -20℃. Avoid multiple/freeze thaw cycles.
• Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
• Tag: Non

Gene Information

• Gene Name: MUC1
• Synonyms: mucin 1, cell surface associated; EMA; PEM; PUM; MAM6; PEMT; CD227; H23AG; MUC-1/X; MUC1/ZD; MUC-1/SEC; episialin; DF3 antigen; H23 antigen; MUC1 isoform T10; MUC1 isoform T11; MUC1 isoform T12; MUC1 isoform T13; OTTHUMP00000033787; OTTHUMP00000033790; OTTHUMP00000033795; mucin 1, transmembrane; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; MUC1_HUMAN; MUC-1; episialin; CD227 antigen; Tumor-associated epithelial membrane antigen; Tumor-associated mucin; mucin 1, transmembrane; tumor associated epithelial mucin.
• Gene ID: 4582
• mRNA Refseq: NM_001018016
• Protein Refseq: NP_001018016
• MIM: 158340
• UniProt ID: P15941
• Chromosome Location: 1q21
• Function: hormone activity

Reviews

08/17/2022

Invaluable for our critical protein analysis experiments.

11/13/2021

Expert guidance, improves the quality of our protein samples.

08/15/2021

Cost-efficient assays, fit well within our research budget.

Q&As

Why is CA15-3 often used as a biomarker in certain types of cancer?

CA15-3 is released into the bloodstream from tumor cells, making it a potential marker for monitoring certain cancers, especially breast cancer.

How does CA15-3 differ structurally and functionally from CA15?

CA15-3 is a specific epitope or form of the CA15 protein, making it distinct in terms of detection.

Are there physiological conditions other than cancer that can elevate CA15-3 levels?

Some benign conditions, like liver disease or benign breast disorders, can elevate CA15-3 levels.

How do CA15-3 levels correlate with disease progression or treatment efficacy?

Elevated CA15-3 levels may indicate tumor presence or growth, while decreasing levels might suggest effective treatment.

Are there any known factors that can interfere with CA15-3 detection assays?

Hemolysis, certain medications, or other non-cancerous conditions might interfere with assay results.

What methods are commonly used to detect and quantify CA15-3 in biological samples?

Immunoassays, such as ELISA, are commonly used for CA15-3 detection.

What is the sensitivity and specificity of CA15-3 in cancer diagnostics?

Sensitivity and specificity vary by test, but CA15-3 is typically used in conjunction with other markers and tests.